Table 1.

Results from models tested in this work on Kaggle OpenVaccine public leaderboard, private test set, and orthogonal mRNA degradation results. ¹Bootstrapped Spearman correlation of degradation rate (resampled from experimental error) to half-life.

	Public test set (400 constructs, 27200 nucleotides)	Private test set (1801 constructs, 162316 nucleotides)	mRNA degradation prediction from ref. 6 (188 constructs)
Metric	MCRMSE	MCRMSE	Spearman Correlation
Experimental error	0.12491	0.10571	0.88
Single Model (blind prediction)
DegScore	0.39219	0.47297	0.36
DegScore-XGBoost	0.35854	0.43850	0.42
Nullrecurrent	0.22758	0.34198	0.43
Kazuki2	0.22756	0.34266	0.48
Ensembled models (post hoc)
Genetic algorithm (10 of top 100 selected)	0.2237	0.3397
Ensemble top 2 models	0.2244	0.33788	0.47
Genetic algorithm on private test set		0.3382	--