Figure 2 |. Binding Antibody and Neutralizing Antibody Titers.
SARS-CoV-2 IgG binding antibody titers (A-C) and pseudovirus neutralization IU50/mL titers (D-F) at Study Day 1 (baseline), Study Day 15 (post-boost), and Study Day 29 (subset analysis; day 29 data not available for all groups). Binding antibody responses to wildtype (S-2P-WA-1 control), as measured by 4-plex ECLIA, and neutralizing antibody (NAb) levels to D614G, grouped by primary EUA immunization regimen (Ad26.COV2.S, mRNA-1273 and BNT162b2) and booster dosing are depicted. Titers were bridged to international standards and reported as Binding Antibody Units/mL and International Units (IU) 50% inhibitory dose/mL (IU50/mL). Individual values are shown as grey circles. Box plots represent median (horizontal line within the box) and 25th and 75th percentiles (lower and upper borders of the box), and the whiskers drawn to the value nearest to, but within, 1.5 times the interquartile range below and above the 25th and 75th percentile, respectively. The red dots represent participants possessing detectable antibody to the SARS-CoV-2 nucleocapsid protein at enrollment, indicative of a prior SARS-CoV-2 infection.