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[Preprint]. 2021 Oct 15:2021.10.03.21264320. [Version 2] doi: 10.1101/2021.10.03.21264320

Figure 3: Ability of vaccine-induced antibodies to neutralize live SARS-CoV-2 following one and two COVID-19 vaccine doses.

Figure 3:

Panel A: Viral neutralization activities, defined as the lowest reciprocal plasma dilution at which neutralization was observed in all triplicate assay wells, following one dose of a COVID-19 vaccine in PLWH (black circles) and controls (grey circles) who were COVID-19 naive at study entry. Convalescent participants (those with anti-N antibodies at study entry, are colored as above. Red bars and whiskers represent median and IQR. P-values were computed using the Mann-Whitney U-test and are uncorrected for multiple comparisons. LLOD: assay lower limit of detection. ULOQ: assay upper limit of quantification. Panel B: Viral neutralization activities after two vaccine doses, colored as in A. Panel C: Correlation between most recent CD4+ T-cell count and viral neutralization activities after one dose (red circles) and two doses (blue circles). Dotted lines are to help visualize the trend.