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. 2021 Oct 20;9(2):e01246-21. doi: 10.1128/Spectrum.01246-21

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Copyright © 2021 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — Epigenetic regulation of SCFAs on HAdV reactivation. (A) Histone modification of tonsil samples upon SCFA treatment. The HAdV-positive lymphocytes were isolated and cultured. The lymphocytes were treated with PBS or tested concentrations of SCFAs for 24 h. The protein levels of Ac-H3-K9, Ac-H3-K18, H3K9me3, H3K27me3, and GAPDH were detected by Western blot analysis. (B) Association of HAdV DNA with modified histones by ChIP assay. The lymphocytes containing HAdV were isolated and cultured. The lymphocytes were treated with PBS or tested concentrations of SCFAs for 6 h. The immunocomplexes of anti-Ac-H3-K9, Ac-H3-K18, H3K9me3, and H3K27me3 were detected for the promoter DNA of HAdV E1A and E2.