FIG 4.

Context-specific gene regulatory networks of Leishmania-infected macrophage and multilayered network analysis reveal potential new therapeutic targets and drug repurposing for host-directed antileishmanial therapies. Our network analysis reveals a final set of 5 possible drug targets; these 5 targets interact with 11 different drugs. Our literature mining reveals that at least 3 drugs were validated in in vitro or in vivo models to test their potential as antileishmanial drugs (46, 47, 80, 99, 100).