TABLE 2.

Summary of treatment-related adverse events occurring in >1 patient

Preferred term, MedDRA dictionary 19.1	Lubiprostone 12 mcg BID (n = 56), no. (%)	Lubiprostone 24 mcg BID (n = 31), no. (%)	Total (N = 87), no. (%)
Diarrhea	3 (5.4)	3 (9.7)	6 (6.9)
Nausea	4 (7.1)	0 (0.0)	4 (4.6)
Abdominal pain upper	1 (1.8)	2 (6.5)	3 (3.4)
Abdominal pain	1 (1.8)	1 (3.2)	2 (2.3)
Dyspepsia	2 (3.6)	0 (0.0)	2 (2.3)
Chest pain	2 (3.6)	0 (0.0)	2 (2.3)
Blood uric acid decreased	2 (3.6)	0 (0.0)	2 (2.3)
Decreased appetite	1 (1.8)	1 (3.2)	2 (2.3)
Headache	3 (5.4)	1 (3.2)	4 (4.6)

BID = twice daily; MedDRA = Medical Dictionary for Regulatory Activities; n = subgroup of total population; N = total population.