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. 2021 Sep 16;33(6):648–657. doi: 10.1097/CCO.0000000000000792

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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Biological aging and multiple myeloma. (a) Biological process of aging and senescence in multiple myeloma patients. CT, computer tomography; DXA, imaging like dual-energy X-ray absorptiometry; SASP, senescence-associated secretory phenotype; TUG, time up and go test. (b) Frailty measures and biomarkers of aging in multiple myeloma patients. Adapted with permission from Soto Perez de Celis, Lancet Oncol, 2018; Cook, Leukemia, 2020. Adapted with permission from Dr A. Rosko's pivotal work/slides and American Federation for Aging Research (AFAR).