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. 2021 Sep 16;33(6):648–657. doi: 10.1097/CCO.0000000000000792

FIGURE 3.

FIGURE 3

Myeloma-specific risk scores. (a) Examples of geriatric assessment tools for myeloma patients. ADL, activity of daily living; BFI, Brief Fatigue Inventory; CCI, Charlson Comorbidity Index; ECOG, Eastern Cooperative Oncology Group; IADL, Instrumental Activities of Daily Living; KPS, Karnofsky Performance Status; MM, multiple myeloma; SF-2612, Short Form 36/12; TUG, Time Up and Go test. (b) Multivariable cox proportional hazard model and weights of 12 comorbidities of the revised Myeloma Comorbidity Index (R-MCI). eGFR, estimated glomerular filtration rate; HR, hazard ratio; KPS, Karnofsky Performance Status; n, number. (c) Examples of myeloma-specific risk scores. ADL, activity of daily living; AE, adverse event; CCI, Charlson Comorbidity Index; CG, cytogenetic; CRP, c-reactive protein; eGFR, estimated glomerular filtration rate; GAH, Geriatric Assessment in Hematology; IADL, Instrumental Activities of Daily Living; IMWG, International Myeloma Working Group; ISS, International Staging System; KPS, Karnofsky Performance Status; MRP, Myeloma Research Alliance Risk Profile; OS, overall survival; PFS, progression-free survival; PS, Performance Status; QoL, quality of life; UK, United Kingdom. (d) Examples of multidimensional functional tests. ADL, activity of daily living; IADL, Instrumental Activities of Daily Living; KPS, Karnofsky Performance Status; NRS, Numerical Rating Scale; SF-12, Short Form 12; TUG, Time Up and Go test. (e) Frailty index risk factors and dose adjustments with the aid of R-MCI. bw, bodyweight; cy, cycle; d, day; i.v., intravenous; R-MCI, Revised Myeloma Comorbidity Score; s.c., subcutaneous; wk, week.