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. 2021 Oct 6;9:700864. doi: 10.3389/fcell.2021.700864

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Copyright © 2021 Hu, Xu, Wang, Feng, Zhang, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The symptoms of dextran sulfate sodium (DSS)-induced colitis were significantly increased at 3 days. (A) Body weight in the control group and DSS-induced group (n = 10 per group) for 0 to 7 days. (B) Disease activity index (DAI) of each group (n = 10) for 0, 3, 5, and 7 days. (C,D) Colon lengths (n = 10). (E) Sections of colon tissues stained with hematoxylin and eosin (H&E) and (F) histology scores from the two groups. Data represent mean ± SD with three independent experiments. One-way ANOVA and Bonferroni tests for multiple testing were applied in all cases. **p < 0.01, ***p < 0.001, ****p < 0.0001. Scale bar = 500 and 100 μm.