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. 2021 Oct 6;9:700864. doi: 10.3389/fcell.2021.700864

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Copyright © 2021 Hu, Xu, Wang, Feng, Zhang, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BMP4 alleviates DSS-induced colitis. (A,B) Body weight and DAI score of mice treated with DSS. At day 3, the control group was administered with saline, the BMP4 group was administered with BMP4, and the BMP4 antibody group was administrated with anti-BMP4 antibody. (C,D) Colon length from different groups. (E) Sections of colon tissues stained with H&E and (F) histology scores from different groups. n = 10 (control), n = 10 (BMP4), n = 10 (anti-BMP4). Data represent mean ± SD with three independent experiments. One-way ANOVA and Bonferroni tests for multiple testing were applied in all cases. *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar = 500 and 100 μm.