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. 2021 Oct 6;9:700864. doi: 10.3389/fcell.2021.700864

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Copyright © 2021 Hu, Xu, Wang, Feng, Zhang, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BMP4 maintains epithelium cell proliferation and Lgr5⁺ ISCs following DSS-induced injury. (A) Immunofluorescence staining for Ki67 in colon tissue from DSS-induced mice treated with saline, BMP4, or anti-BMP4 antibody (red: Ki67, blue: DAPI). (B) Quantification of Ki67-positive cells per crypt (n = 5). (C) Immunofluorescence staining for Lgr5 in colon tissue from DSS-induced mice treated with saline, BMP4, or anti-BMP4 antibody (green: Lgr5, blue: DAPI). (D) Quantification of Lgr5-positive cells per crypt (n = 5). Data represent mean ± SD with three independent experiments. One-way ANOVA and Bonferroni tests for multiple testing were applied in all cases. ***p < 0.001. Scale bar = 25 μm.