Scheme 1. Synthesis of 5′-O-propargyluridine (8). Reagents and conditions: (a) (i) acetone, H2SO4, 0 °C to r.t, overnight, >99%; (ii) propargyl bromide, NaH, THF, 0 °C to r.t, overnight, 70%; (b) In(OTf)3, ACN/H2O (9 : 1), reflux, 6 h, >99%.
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