Yields for protected triazoles 12a–g from the copper azide-alkyne cyclisation coupling of 5′-O-propargyluridine (8) and α-azidophosphonates (11a–g), followed by their deprotection to form the final deprotected 1,2,3-triazole series in their Na⁺ salt form (13a–g).

R1	Click yield (R2: OBn)a	Deprotection yield (R2: O−Na+)b
	12a: 51%	13a-(s): 99%
		13a-(l): 91%
	12b: 52%	13b-(s): 94%
		13b-(l): 99%
	12c: 66%	13c-(s): 97%
		13c-(l): 91%
	12d: 57%	13d-(s): 92%
		13d-(l): 62%
	12e: 60%	13e-(s): 92%
		13e-(l): 85%
	12f: 52%	13f-(s): 95%
		13f-(l): 92%
	12g: 57%	13g-(s): 96%
		13g-(l): 92%

^aYield of corresponding 1,2,3-triazole linked product from CuAAC click coupling (12a–g, Scheme 2).

^bYield of final compound after catalytic hydrogenation deprotection and RP-HPLC separation and purification of diastereomers (13a–g, Scheme 2).