Inhibitory activity of compounds against hST3Gal I and hST6Gal I.
| Compound | hST6Gal I | hST3Gal I | ||
|---|---|---|---|---|
| Inhibition at 10 μM (%) | K m or Ki (μM) | K m/Ki | Inhibition at 100 μM (%) | |
| CMP-Neu5Ac | — | 37 ± 5 | — | — |
| 4-(l) | 59 | 1.1 ± 0.1 | 32.5 | 38 |
| 5-(s/l) | 84a | — | — | 43 |
| 13a-(s) | 62 | 40 ± 10 | 1.0 | 28 |
| 13a-(l) | 26 | 50 ± 10 | 0.7 | 2 |
| 13b-(s) | 41 | — | — | — |
| 13b-(l) | 10 | — | — | — |
| 13c-(s) | 57 | 6 ± 1 | 6.0 | 43 |
| 13c-(l) | 59 | 34 ± 6 | 1.1 | 9 |
| 13d-(s) | 44 | — | — | — |
| 13d-(l) | 45 | — | — | — |
| 13e-(s) | 39 | — | — | — |
| 13e-(l) | 23 | — | — | — |
| 13f-(s) | 65 | 6.7 ± 0.6 | 5.6 | 49 |
| 13f-(l) | 78 | 3.4 ± 0.6 | 11.0 | 39 |
| 13g-(s) | 25 | — | — | — |
| 13g-(l) | 21 | — | — | — |
a
Inhibition for this compound was recorded at 100 μM inhibitor concentration.