Fig. 4. Analysis of the top 200 ROCS ranked BRD4 or L3MBTL1 ligands in the ChEMBL database compared with exemplar compounds bearing privileged epigenetic chemotypes. Count refers to the ROCS ranking where 1 is the best ranked compound (most similar). A: Compound 10 (black) or the scaffold of JQ1 (blue) vs. BRD4 ligands deposited to ChEMBL (2168 molecules). B: Compound 17 (black) or UNC669 (blue) vs. L3MBTL1 ligands deposited to ChEMBL (10 847 molecules, UNC669 was removed from the test set).
