. 2021 Aug 24;12(10):1765–1770. doi: 10.1039/d1md00215e

IC₅₀, K_i and α values derived from the displacement curves measured by competitive ¹⁹F NMR for compound 15b and VHL homo-PROTACs. The respective α values previously reported by ITC were added for comparison.

PROTAC	Target	¹⁹F NMR			ITC
PROTAC	Target	IC₅₀ (nM)	K _i (nM)	α	α
15b	—	3022	2058	—	—
15b	Brd4(2)	346	71	29	15
CMP99	—	888	287	—	—
CM11	—	277	39	7	13

IC50, Ki and α values derived from the displacement curves measured by competitive 19F NMR for compound 15b and VHL homo-PROTACs. The respective α values previously reported by ITC were added for comparison.