Fig. 2. Violin plots displaying the distribution of molecular weight, clog P and topological polar surface area (TPSA). Displayed is the range of values with the median (thick dotted line) and interquartile ranges (thin dotted line). The graph thickens in relation to more data points. All data points are shown for the PPI modulators which have been approved (approved) and those currently in clinical trials (clinical trial). Due to the large data set, these are not displayed for the non-PPI compounds which have been approved for use²⁶ (non-PPI) and the PPI inhibitors collated in the iPPI-DB^7,8 (iPPI-db).