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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Am J Psychiatry. 2020 Aug 28;178(1):39–47. doi: 10.1176/appi.ajp.2020.19080886

Figure 3. Brain regions significant in the linear mixed effects model for the reward processing contrast.

Figure 3.

(A) Axial slices showing brain regions that were significant in the linear mixed-effects model of the interactive effect of voxel-activation during reward processing, treatment group and week on (Child’s) Yale-Brown Obsessive Compulsive Scale ((C)Y-BOCS) scores. All regions are presented at an uncorrected cluster forming threshold of p<0.001 and a familywise error corrected cluster threshold of p<0.05. Blue indicates regions where more pre-treatment activation was associated with greater symptom reduction over time in patients undergoing CBT, but a smaller reduction in symptoms over time in patients undergoing SMT. Red indicates regions where more pre-treatment activation was associated with a smaller reduction in symptoms over time in patients undergoing CBT, but a greater reduction in symptoms over time in patients undergoing SMT. (B) Graphs showing predicted model estimates for cognitive behavioral therapy (CBT) and stress management therapy (SMT) groups. The y-axis represents the predicted (C)Y-BOCS based on model estimates, and separate lines indicate level of vmPFC/OFC/amygdala/IFG/DLPFC activation (“Low” = one standard deviation below mean, “Medium” = mean, “High” = one standard deviation above the mean). Graphs for other regions are given in the Supplement.