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. 2021 Oct 20;16(10):e0258755. doi: 10.1371/journal.pone.0258755

Fig 4. Histopathology of skin nodules.

Fig 4

a) Acanthosis (green arrow), associated with hydropic degeneration in keratinocytes of the epidermal layer of the skin (black arrow), while the next dermal layer is normal (H&E; Bar = 100μm). b) Vasculitis (green arrow), associated with massive leucocytic infiltrations in the dermal layer (black arrow) (H&E; Bar = 100μm). c) Intracytoplasmic inclusion body of LSD in the keratinocytes of the epidermal layer (black arrow), while the dermal layer shows massive leucocytic infiltrations mainly by eosinophils (green arrow) (H&E; Bar = 50μm). d) Chromatin condensation and calcium deposits in keratin layer (black arrows), while the next dermal layer shows severe hemorrhages with leucocytic aggregation (H&E; Bar = 200μm). e) Necrosis and dissociation of muscle fibers, fatty infiltrates, and leucocytic infiltration mainly by lymphocytes and few numbers of eosinophils between them (black arrows) (H&E; Bar = 100 μm). f) Dilatation of lymph vessels (LVs.), necrotizing vasculitis (black arrow), and leucocytic infiltration mainly by lymphocytes and few numbers of eosinophils between them (green arrows) (H&E; Bar = 200 μm). g) Red viral particles in macrophage of connective tissue of the dermal layer (black arrows) using alkaline phosphatase immunohistochemistry).