Table 4.
Permeation parameters of ACZ from various formulations across goat cornea.
Formulation | Amount of ACZ permeated/ unit area (Q/A) after 6 h (µg·cm−2) | Lag time (min) | Steady state permeation (J) (µg·cm−2·h−1) | Permeability coefficient (cm·s−1) |
---|---|---|---|---|
F1 | 1267.1 ± 67.1 | 0 | 204.2 | 7.09 × 10−6 |
F5 | 2007.3 ± 64.3 | 0 | 459.8 | 1.597 × 10−5 |
F6 | 1101.5 ± 100.7 | 0 | 167.8 | 5.826 × 10−6 |
F7 | 1591 ± 111.4 | 0 | 283.6 | 9.847 × 10−6 |
F8 | 923.2 ± 48.4 | 0 | 147.7 | 5.128 × 10−6 |