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. 2021 Oct 7;8(10):2070–2082. doi: 10.1002/acn3.51456

Figure 5.

Figure 5

PAP‐1 treatment and Kv1.3 deletion reduce Iba‐1 and CD3 staining in 80‐week‐old female mice. Serial paraffin sections (5 µm thick) cut at 4 mm and the 6 mm from 80‐week‐old female mice were stained for Iba‐1 and CD3. (A) Percentage of Iba‐1‐positive pixels in the infarcted hemisphere. Vehicle‐treated WT (n = 9), PAP‐1‐treated WT (n = 9, p = 0.120 for 4‐mm section; p = 0.014 for 6‐mm section), and Kv1.3−/− (n = 18, p = 0.011 for 4‐mm section; p = 0.007 for 6‐mm section). (B) Percentage of CD3‐positive pixels in the infarcted hemisphere. Vehicle‐treated WT (n = 9), PAP‐1‐treated WT (n = 9, p = 0.049 for 4‐mm section; p = 0.027 for 6‐mm section), and Kv1.3−/− (n = 18, p < 0.001 for 4‐mm section; p = 0.002 for 6‐mm section). Data are shown as whisker plots with individual data overlay. The boxes show mean ± SEM and the whiskers show confidence intervals.