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Novel intervention targets for severe alcohol withdrawal syndrome beyond GABA and glutamate. BK = large conductance calcium-activated potassium channel, CCL2 = C-C motif chemokine ligand 2; GABA = γ-aminobutyric acid; GIRK = G protein–coupled inwardly-rectifying potassium channel; L-type Ca2+ = high voltage–activated calcium channel; SK = small conductance calcium-activated potassium channel; T-type Ca2+ = low voltage–activated calcium channel.
