Table 3.
Percent parasitemia and percent parasitemia inhibition of P. berghei-infected mice treated with crude hydromethanolic extract and chloroform fraction of B. antidysenterica leaves in the curative test.
| Extract | Day 3 %Para. Supp. | Day 4 %Para. Supp. | Day 5 | Day 6 %Para. Supp. | Day 7 %Para. Supp. | |
|---|---|---|---|---|---|---|
| Average percent parasitemia | %Para. Supp. | |||||
| CON10 ml/kg | 14.10 ± 0.54 | 34.00 ± 0.83 | 45.13 ± 0.48 | 0.00 | 0.00 | 0.00 |
| CM100 mg/kg | 15.00 ± 0.37 | 27.03 ± 0.81 | 24.03 ± 0.68acd(3) | 46.75 | 23.07 ± 0.42 | 18.96 ± 0.78 |
| CM200 mg/kg | 14.03 ± 0.60 | 26.07 ± 0.46 | 17.10 ± 1.05abe(3)d2 | 62.11 | 13.27 ± 0.31 | 10.00 ± 0.47 |
| CM400 mg/kg | 15.10 ± 0.18 | 29.00 ± 0.30 | 13.13 ± 0.18abe(3)c2 | 70.90 | 9.07 ± 2.00 | 7.50 ± 0.17 |
| CF100 mg/kg | 12.13 ± 0.20 | 25.00 ± 0.24 | 22.43 ± 0.95acde(3) | 50.30 | 20.30 ± 0.60 | 16.40 ± 0.54 |
| CF200 mg/kg | 14.05 ± 0.31 | 20.00 ± 0.52 | 15.57 ± 0.68abde(3) | 65.50 | 11.93 ± 0.72 | 9.63 ± 0.38 |
| CF400 mg/kg | 15.13 ± 0.53 | 7.07 ± 0.14 | 9.00 ± 0.15abce(3) | 80.06 | 8.70 ± 0.30 | 7.30 ± 0.33 |
| CQ10 mg/kg | 13.10 ± 0.38 | 34.00 ± 0.83 | 3.10 ± 0.22abcd(3) | 93.13 | 0.00 ± 0.00 | 0.00 ± 0.00 |
Data are expressed as mean ± SEM. n = 6; CON = negative control; CM = crude hydromethanolic extract, CF = chloroform fraction of B. antidysenterica; CQ = chloroquine; % Para. Supp. = percent parasitemia suppression. a, compared with negative control; b, compared with 100 mg/kg; c, compared with 200 mg/kg; d, compared with 400 mg/kg; e, compared with CQ10 mg/kg: 2, p < 0.01; 3, p < 0.001..