. 2021 Oct 11;8:1769–1776. doi: 10.1016/j.toxrep.2021.10.005

Table 2.

Effect of T. catappa aqueous extract single-dose treatment on some biochemical and proinflammatory parameters in the acute toxicity study.

Parameters	Control	1000 mg/kg	2500 mg/kg	5000 mg/kg
ALT (U/I)	8.55 ± 2.57^a	5.82 ± 1.82^b	5.26 ± 1.42^b	1.97 ± 0.74^c
AST (U/I)	29.39 ± 6.97^b	25.57 ± 2.58^b	25.32 ± 13.61^b	15.11 ± 6.14^a
ALP (U/I)	523.30 ± 10.35^a	547.50 ± 9.20^a	505.06 ± 22.20^a	536.50 ± 7.87^a
ALB (g/L)	36.14 ± 1.61^a	33.10 ± 0.79^a	32.36 ± 2.14^a	34.20 ± 1.06^a
BIL (mg/dL)	0.69 ± 0.35^a	1.25 ± 0.87^a	0.95 ± 0.40^a	1.45 ± 0.95^a
TP (mg/mL)	70.03 ± 5.82^a	72.11 ± 6.32^a	77.83 ± 3.28^a	74.57 ± 7.24^a
Urea (mg/dL)	32.68 ± 2.55^a	37.64 ± 2.10^a	34.47 ± 2.00^a	29.78 ± 2.00^a
Crea (mg/dL)	0.56 ± 0.04^a	0.39 ± 0.11^a	0.48 ± 0.05^a	0.61 ± 0.09^a
Na (mEQ /L)	91.13 ± 5. 84^a	95.53 ± 6.78^a	92.27 ± 8.43^a	91.19 ± 7.21^a
Ca (mg/dL)	8.94 ± 1.47^a	9.32 ± 0.89^a	9.43 ± 1.15^a	8.97 ± 0.57^a
HCO₃(mmol/L)	33.77 ± 4.02^a	29.78 ± 2.74^a	31.15 ± 3.61^a	28.88 ± 2.87^a
UA (mg/dL)	9.52 ± 0.94^a	8.02 ± 0.12^a	7.71 ± 1.74^a	9.31 ± 0.98^a
IL-6 (pg/mL)	28.38 ± 6.77^a	20.63 ± 4.13^a	25.84 ± 7.31^a	28.00 ± 4.21^a
TNF-α (pg/mL)	9.37 ± 1.56^a	11.22 ± 2.60^a	13.11 ± 2.59^a	8.88 ± 1.24^a
Insulin (mIU/L)	18.41 ± 1.03^a	19.22 ± 1.74^a	16.97 ± 2.16^a	18.66 ± 1.47^a

Data are presented as mean ± SEM (n=5). Values with different superscripts (^a.b) across a row are significantly different at p<0.05. ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; ALB: albumin; BIL: bilirubin; Crea: creatinine; HCO₃: bicarbonate; UA: uric acid; TP: total protein; IL-6: interleukin VI; TNF-α: tumour necrosis factor-alpha.