. 2021 Oct 11;8:1769–1776. doi: 10.1016/j.toxrep.2021.10.005

Table 4.

Effect of T. catappa aqueous extract 28-day repeated dose treatment on some biochemical and proinflammatory parameters in the sub-acute toxicity study.

Parameters	Control	200 mg/kg	400 mg/kg	800 mg/kg
ALT (U/I)	5.97 ± 0.46^a	4.94 ± 1.82^b	4.33 ± 1.42^b	1.86 ± 0.74^c
AST (U/I)	28.52 ± 5.10^a	42.98 ± 4.86^a	43.71 ± 7.88^a	38.96 ± 4.29^a
ALP (U/I)	226.14 ± 35.76^a	296.81 ± 6.76^b	267.14 ± 12.56^b	335.55 ± 35.45^c
ALB (g/L)	35.26 ± 2.32^a	36.53 ± 2.42^a	40.62 ± 2.22^b	43.52 ± 1.75^c
BIL (mg/dL)	0.94 ± 0.11^a	0.90 ± 0.17^a	0.86 ± 0.24^a	0.92 ± 0.23^a
TP (mg/mL)	63.61 ± 2.03^a	62.80 ± 1.54^a	66.11 ± 1.35^a	64.41 ± 2.07^a
Urea (mg/dL)	30.31 ± 3.59^a	27.46 ± 3.66^a	27.28 ± 1.77^a	28.19 ± 0.61^a
Crea (mg/dL)	0.57 ± 0.19^a	0.60 ± 0.13^a	0.63 ± 0.16^a	0.81 ± 0.01^a
Na (mEQ /L)	91.11 ± 6.32^a	89.33 ± 12.53^a	90.28 ± 13.89^a	95.18 ± 4.65^a
Ca (mg/dL)	8.34 ± 1.87^a	8.94 ± 1.98^a	8.08 ± 0.53^a	8.55 ± 1.89^a
HCO₃(mmol/L)	36.65 ± 4.55^a	34.32 ± 5.54^a	34.67 ± 5.26^a	34.22 ± 4.55^a
UA (mg/dL)	12.95 ± 2.33^a	11.32 ± 0.71^a	14.17 ± 2.99^a	16.63 ± 3.39^a
IL-6 (pg/mL)	25.71 ± 3.47^a	27.22 ± 4.70^a	22.39 ± 6.88^a	20.75 ± 5.61^a
TNF-α (pg/mL)	28.34 ± 1.87^a	28.94 ± 1.98^a	30.08 ± 7.53^a	25.55 ± 4.89^a
Insulin (mIU/L)	15.35 ± 5.03^a	18.92 ± 6.14^a	15.67 ± 3.12^a	13.66 ± 4.24^a

Data are presented as mean ± SEM (n=5). Values with different superscripts (^a.b) across a row are significantly different at p<0.05. ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; ALB: albumin; BIL: bilirubin; Crea: creatinine; HCO₃: bicarbonate; UA: uric acid; TP: total protein; IL-6: interleukin VI; TNF-α: tumour necrosis factor-alpha.