Skip to main content
. 2021 Jul 23;45(11):2377–2387. doi: 10.1038/s41366-021-00902-6

Fig. 3. IL-4Rα weight gain-associated sequelae are dependent on the presence of combined high carbohydrate and high-fat diet feeding.

Fig. 3

WT and IL-4Rα−/− mice were fed a HC diet for 12 weeks and were subsequently switched to a HF or HF + HC diet for an additional of 12 weeks (24 weeks in total). A Total body weight gain over time. B Serum fasting glucose levels at week 12 of dietary challenge. C Glucose tolerance test at 12 weeks of dietary challenge. D Area under the curve (AUC) of glucose tolerance test at 12 weeks of dietary challenge. E Liver triglycerides at time of harvest. F Systemic alanine transaminase (ALT) levels at time of harvest. A–F Representative of 2 independent experiments, n = 5–6/condition. In bar graphs and line graphs data represents mean ± SEM. A Unpaired two-tailed Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. C, D Area under the curve (AUC). B, E, F One-way ANOVA followed by multiple comparisons. *P < 0.05, **P < 0.01, ***P < 0.001.