FIG. 3.

Sequence alignment of the predicted AdoMet-binding region of Spb1p from S. cerevisiae with potential homologues from different species. Eight predicted proteins from different organisms possess significant similarities with the N-terminal moiety of Spb1p from S. cerevisiae (Sc; accession number, CAA42391) as follows: Bc, Botryotinia fuckeliana (AL111693); Sp, Schizosaccharomyces pombe pmt2 (CAA22605); Mm, Mus musculus (AI574417); Cp, Cryptosporidium parvum (AQ450296); At, Arabidopsis thaliana (CAB39594); Hs, Homo sapiens JM23 (HSA005892); Ce, Caenorhabditis elegans (CAA85279); and Ec, E. coli (74) (AAC76211). Residues identical between the different species are on a black background, and the ones that are similar are on a gray background. The four motifs (I, post I, II, and III) that form the putative AdoMet-binding domain are boxed.