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. 2021 Aug 20;14(6):1347–1357. doi: 10.1038/s41385-021-00439-x

Fig. 6. Alternate integrin αEβ7-independent and dependent models of IgA transcytosis.

Fig. 6

a Canonical diffusion model for IgA transcytosis in which dIgA is secreted by IgA + ASC into the extracellular milieu and diffuses to reach pIgR. b Proposed new model of αEβ7-dependent IgA transcytosis in which αEβ7 + IgA + ASC dock with IEC to directly relay dIgA to pIgR for transcytosis into the intestinal lumen.