Figure 1.

Cerebral vascular amyloid deposition in human brain tissues. Brain tissue sections from patients with CAA (A) and with no disease or amyloid plaques (non-CAA) (B). Thioflavin-S was used to identify vascular amyloid (green), and an anti-collagen IV antibody was used to identify cerebral blood vessels (red). The tissue slice in (A) shows a cross section of a blood vessel (arrow) and a longitudinal section of a blood vessel (double arrows) exhibiting amyloid buildup. In a mixture of vascular and parenchymal deposits, labeling of both the amyloid and blood vessels allows one to identify vascular amyloid in the presence of parenchymal amyloid. Scale bars = 50 μm.