Table 1.

Prevalence and risk of overall major congenital malformations in pregnancies of second-generation antipsychotic users. Comparisons to the unexposed

Exposure	Prevalence 1/1000	Crude OR*	95% CI	Adjusted** OR	95% CI
Unexposed	43.7	Ref	Ref	Ref	Ref
Any S-GA	54.1	1.20	1.02–1.41	0.92	0.72–1.19
Quetiapine	49.3	1.07	0.88–1.29	0.85	0.64–1.12
Olanzapine	79.9	1.90	1.33–2.73	2.12	1.19–3.76
Risperidone	53.7	1.29	0.73–2.26	1.48	0.75–2.90
Aripiprazole	72.7	1.60	0.96–2.68	1.80	0.74–4.42
Clozapine	37.7	0.88	0.32–2.41	2.00	0.30–13.35

Analyses based on imputed data

S-GA second-generation antipsychotic

^*Adjusted for year of delivery; ^**Adjusted for year of delivery, maternal age at delivery, parity, pre-pregnancy BMI, cohabitation, smoking, SES, other psychiatric drugs, psychotic and other severe mental disorders, pre-gestational diabetes, gestational diabetes

Statistically significant results written in bold