Table 2.

Prevalence and risk of overall major congenital malformations in pregnancies of second-generation antipsychotic users. Comparisons to first-generation antipsychotic users

Exposure	Prevalence 1/1000	Crude OR*	95% CI	Adjusted** OR	95% CI
Any F-GA	58.9	Ref	Ref	Ref	Ref
Any S-GA	54.1	0.88	0.60–1.29	0.82	0.56–1.20
Quetiapine	49.3	0.80	0.52–1.24	0.76	0.49–1.18
Olanzapine	79.9	1.40	0.84–2.32	1.33	0.78–2.27
Risperidone	53.7	0.89	0.47–1.71	0.83	0.42–1.61
Aripiprazole	72.7	1.38	0.68–2.79	1.06	0.50–2.24
Clozapine	37.7	0.67	0.23–1.92	0.51	0.16–1.57

Analyses based on imputed data

S-GA second-generation antipsychotic, F-GA first-generation antipsychotic

^*Adjusted for year of delivery; ^**Adjusted for year of delivery, maternal age at delivery, parity, pre-pregnancy BMI, cohabitation, smoking, SES, other psychiatric drugs, psychotic and other severe mental disorders, pre-gestational diabetes, gestational diabetes