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. 2021 Aug 29;473(11):1749–1760. doi: 10.1007/s00424-021-02611-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effect of LK intake on HCTZ-induced changes in absolute (EK) and fractional (FEK) K⁺ excretion in male and female mice. HCTZ was given by iv bolus injection (30 mg/kg) after two 30-min baseline urine collections. Urinary K⁺ excretion was monitored for 90 min after HCTZ administration. Data are presented as means ± SE. *: Significant difference from the baseline (n = 6, P < 0.05, by one-way ANOVA test), ^‡: Significant difference between CK and LK groups (n = 6, P < 0.05, by one-way ANOVA test)