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. 2021 Oct 20;12:6105. doi: 10.1038/s41467-021-25649-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A SVR rate for patients with different numbers of TOPs in baseline sequences. The dots indicate the SVR rate in each group and the lines indicate its 95% confidence intervals. The numbers in each group are shown at the bottom of the figure. B Covariation between the three novel TOPs and their association with treatment outcome. Combinations tested are listed in the table on the left. The squares show the estimated effect size (log(odds ratio)) for each group and the lines show its 95% confidence interval estimated from logistic regression. The P-value (logistic regression) and the SVR rate for each group are shown on the right.