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. 2021 Oct 20;4:1200. doi: 10.1038/s42003-021-02730-w

Fig. 3. Overexpression of mCAT ameliorates kidney pathology, cystic enlargement, and fibrosis in RC/RC mice.

Fig. 3

a Gross pathology of kidneys from 6−7-month-old WT and RC/RC mice or RC/RC mice that received low dose injection (2 × 109/g) of AAV9-mCAT (RC/RC + AAV9-mCAT) (representative image shown; n = 4−6). b Kidney weight and c heart weight normalized to body weight in mice of the indicated genotypes and treatment groups; n = 10−21. d Blood urea nitrogen (BUN; mg/dL) and Hemoglobin (g/dL) in mice of the indicated genotypes and treatment groups; n = 3−4 per group. e Representative PAS staining of kidney sections from WT, RC/RC, and RC/RC treated with AAV9-mCAT. f, g Trichrome staining of kidney section from RC/RC and RC/RC treated with AAV9-mCAT. Quantitative analysis of h cysts area, i fibrotic area, and j combined cysts and fibrotic area. *p < 0.05.; (n = 4 for WT, n = 15−18 for each of the other groups).