TABLE 2.
Propofol administration comparison by arm
| Outcome Measure | EMLA cream N=75 |
Placebo Cream N=77 |
P-valuea |
|---|---|---|---|
|
Total Propofol Dose (mg/kg) Least Squares Mean (SE) |
2.94 (0.25) | 3.22 (0.19) | 0.036 |
|
Additional Propofol Administered (Yes/No) Mean Probability of Yes (SE) |
0.49 (0.08) | 0.69 (0.06) | 0.001 |
|
Anesthesia Time (minutes) Least Squares Mean (SE) |
16.1 (1.0) | 17.4 (0.9) | 0.348 |
|
LP time (minutes)
Least Squares Mean (SE) |
5.6 (0.5) | 6.0 (0.7) | 0.570 |
|
Time from Induction to end of LP
Least Squares Mean (SE) |
7.9 (0.4) | 8.4 (0.7) | 0.501 |
|
Lowest BP Systolic (mm Hg) Least Squares Mean (SE) |
85.1 (1.8) | 85.1 (2.0) | 0.985 |
|
Lowest BP Diastolic (mm Hg) Least Squares Mean (SE) |
41.9 (1.3) | 42.2 (1.2) | 0.834 |
|
Lowest BP Percent Systolic (%) Least Squares Mean (SE) |
15.8 (3.5) | 19.4 (4.2) | 0.411 |
|
Lowest BP Percent Diastolic (%) Least Squares Mean (SE) |
16.3 (2.6) | 18.9 (3.8) | 0.415 |
|
Post-LP Headache (Yes/No)b Mean Probability of Yes (SE) |
0.19 (0.04) | 0.29 (0.06) | 0.094 |
|
Post-LP Back Pain (Yes/No)c Mean Probability of Yes (SE) |
0.21 (0.05) | 0.25 (0.05) | 0.426 |
EMLA, eutectic mixture of lidocaine and prilocaine; SE, standard error
a
p-value from Generalized Estimating Equation marginal model
b
for post-LP headache, N=68 for EMLA cream and N=73 for placebo
c
for post-LP back pain, N=69 for EMLA cream and N=74 for placebo