Skip to main content
. 2021 Oct 20;11:542. doi: 10.1038/s41398-021-01594-2

Fig. 3. Bilobalide induces the expression of Aβ degrading enzymes to facilitate Aβ clearance in primary astrocyte culture.

Fig. 3

A Western blot and its quantification showing the protein levels of NEP, IDE, and MMP2 in astrocyte culture treated by bilobalide at indicated concentrations. B Aβ clearance assay showing Aβ42 levels in the culture medium of astrocytes treated by bilobalide at indicated concentrations. C Diagram showing the astrocyte-neuron co-culture in transwell system. D ELISA results showing Aβ40 and Aβ42 levels in the culture medium of APP/PS1 neuron co-cultured with control or bilobalide (5 μM) pretreated astrocytes. *P < 0.05, **P < 0.01, ***P < 0.001.