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. 2021 Oct 7;12:737973. doi: 10.3389/fimmu.2021.737973

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Copyright © 2021 Thornlow, Macintyre, Oguin, Karlsson, Stover, Lynch, Sempowski and Schmidt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epitope mapping gHA elicited serum response. A serum competition ELISA with structurally characterized antibodies was used to epitope map elicited serum responses by gHA immunogens: gHA^RBSv2.0 (A), gHA^shield (B), gHA_cys ^RBSv2.0 (C) and gHA_cys ^shield (D). Day 28 serum from gHA^RBSv2.0 (A), gHA^shield (B), and gHA_cys ^RBSv2.0 (C) elicited a significant HC45-like response. None of the gHA immunogens elicited a significant FI6-like response. Statistical significance was determined by a student’s t-test with Welch’s correction relative to negative control (5J8). (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).