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. 2021 Oct 7;12:737973. doi: 10.3389/fimmu.2021.737973

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Copyright © 2021 Thornlow, Macintyre, Oguin, Karlsson, Stover, Lynch, Sempowski and Schmidt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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gHA immunogens elicit serum responses with limited breadth and neutralization. (A) Day 28 serum binding against a Luminex panel of antigenically distinct, historical H3 HAs spanning 1975-2012. Serum responses show limited breadth beyond H3Leningrad/360/1986 (x-91) (Len 86). Serum binding is reported as the average mean fluorescence intensity (MFI) minus background for all mice in a specific cohort. (B) Microneutralization of day 28 serum against matched A/Aichi/2/1968 X-31 (H3N2) virus. Endpoint titers are reported as the greatest dilution observed to exhibit ≥50% virus neutralization and are reported as geometric mean of duplicate dilution series. Day 28 serum from each immunogen show weak microneutralization of matched virus.