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PGD is associated with accelerated DNA methylation age. DNA methylation age for non-PGD and PGD subjects was compared in airway cell cultures taken 12 months after lung transplantation. Groups were compared by Mann-Whitney U test. By linear regression, airway methylation age was 6.5 years (95% CI 1.7–11.2 years, P = 0.01) greater for n=15 PGD versus n=13 non-PGD subjects.
