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. 2021 Oct 7;9:731311. doi: 10.3389/fcell.2021.731311

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Copyright © 2021 Huang, Lin, Chen, Lou, Ren, Huang, Zhang, Yu, Guo, Wang, Wang, Niu, Xu, Guo and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between IRLs signature and endogenous immune escape in osteosarcoma. (A–C) The expression of MHC-I molecule, MHC-II molecule, and costimulatory molecule changed with the increase of risk score. (D–F) Differential analysis of the expression of MHC-I, MHC-II, and costimulatory molecules in high-risk and low-risk osteosarcoma. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.