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. 2021 Oct 7;9:731311. doi: 10.3389/fcell.2021.731311

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Copyright © 2021 Huang, Lin, Chen, Lou, Ren, Huang, Zhang, Yu, Guo, Wang, Wang, Niu, Xu, Guo and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of IRLs signature in metastasis and proliferation of osteosarcoma. (A) The probability of metastasis of osteosarcoma gradually decreases with the decrease of risk score. (B) Differential expression of 10 IRLs in metastatic and non-metastatic osteosarcomas. Only the expression level of AC006033.2 was different. (C) Knockdown results of AC006033.2 in osteosarcoma cell lines. (D,E) Effects of AC006033.2 knockdown on proliferation of osteosarcoma cells. *P < 0.05 and ***P < 0.001. EdU, 5-ethynyl-2′-deoxyuridine.