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. 2021 Oct 7;9:731311. doi: 10.3389/fcell.2021.731311

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Copyright © 2021 Huang, Lin, Chen, Lou, Ren, Huang, Zhang, Yu, Guo, Wang, Wang, Niu, Xu, Guo and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between IRLs signature and tumor microenvironment score. (A–C) Analysis of differences in the immune score, stromal score, and Estimate score between high-risk and low-risk osteosarcoma. (D–F) Correlation analysis between risk score and osteosarcoma immune score, matrix score, and Estimate score. (G) Analysis of difference in tumor cell purity between high-risk and low-risk osteosarcoma. (H) Correlation analysis between risk score and tumor cell purity of osteosarcoma.