Table 1.
Differently enriched KEGG pathways with targeted genes of comparisons between chickens with different eggshell colors.
| Comparison | Pathways | p | Targeted genes |
|---|---|---|---|
| DB vs. DP | Transporters | 0.008 | SLC34A1, SLC13A3, SLC35F1, SLC22A6-A, SLC26A1 |
| Exosome | 0.011 | SLC34A1, GSN, CUBN, DSP, HSPG2, FN1, FLNA | |
| Cytoskeleton proteins | 0.041 | GSN, DSP, Tpm3, FLNA | |
| Cortisol synthesis and secretion | 0.028 | Pbx1 | |
| Apoptosis | 0.041 | ITPR2, CASP6 | |
| Glycerophospholipid metabolism | 0.045 | Etnk1 | |
| Lipid metabolism | 0.044 | LPPR4 | |
| DB vs. LB | Transporters | <0.001 | SLC13A3, SLC35F1, SLC25A47, SLC22A6-A, SLC26A1 |
| Exosome | 0.023 | SLC34A1, CUBN, DSP, ANXA11, COL18A1 | |
| Cortisol synthesis and secretion | 0.025 | Pbx1 | |
| NOD-like receptor signaling pathway | 0.028 | ITPR2, TRAF5 | |
| Progesterone-mediated oocyte maturation | 0.034 | PGR, CPEB2 | |
| Glycerophospholipid metabolism | 0.035 | Etnk1 | |
| DP vs. LB | Inositol phosphate metabolism | 0.010 | MTMR1, IPMK |
| Cysteine and methionine metabolism | 0.022 | SRM | |
| Phosphatidylinositol signaling system | 0.024 | MTMR1, IPMK | |
| Protein phosphatase and associated proteins | 0.031 | MTMR1, IPMK, SSH2, SH3RF1 | |
| PK vs. DB | Transporters | <0.001 | SLCO1C1, SLC16A7, SLC34A1, SLC13A3, SLC25A47, SLC22A4, SLC26A1, OCLN, CNNM2, ABCA4 |
| Progesterone-mediated oocyte maturation | 0.002 | PGR, BRAF, ANAPC1, CPEB2 | |
| Ascorbate and aldarate metabolism | 0.012 | Ugt1a9 | |
| Lysosome | 0.034 | Cd164 | |
| General function prediction only | 0.039 | ABHD2 | |
| Glycosyltransferases | 0.041 | STT3B, Ganlt16, Ugt1a9, ST8SIA5 | |
| Butanoate metabolism | 0.048 | .- | |
| PK vs. DP | Transcription factors | 0.004 | PGR, FOXP1, Nr6a1, IRF4, Rfx2, Pbx1 |
| Transporters | 0.006 | SLCO1C1, SLC35F1, SLC4A4, SLC25A47, SLC35F5, SLC22A4 | |
| Hedgehog signaling pathway | 0.007 | GSK3B, PTCH1 | |
| Other glycan degradation | 0.011 | MANBA | |
| Lysosome | 0.016 | MANBA | |
| Nuclear receptors | 0.019 | PGR, Nr6a1 | |
| Cortisol synthesis and secretion | 0.027 | Pbx1 | |
| PK vs. LB | Phosphatidylinositol signaling system | 0.002 | PI4KA |
| Inositol phosphate metabolism | 0.005 | PI4KA | |
| Cortisol synthesis and secretion | 0.026 | Pbx1 | |
| Membrane trafficking | 0.026 | PI4KA | |
| DNA replication proteins | 0.039 | FOXP1, Pbx1 |
DB, DP, LB, and PK mean chickens producing dark blue, dark brown and greenish, light blue, and pink eggshell eggs, respectively.