FIGURE 2.

SB216763 but not AFC03127 inhibits AGS in Fmr1^KO mice. Fmr1^KO mice were treated with 0.5% HPMC vehicle, 30 mg/kg MPEP, 30 mg/kg SB216763, or 10 mg/kg AFC03127 I.P. at P21 and 30 min later tested for susceptibility to wild running (WR), tonic-clonic seizures (AGS), and death in the AGS assay. Treatment groups were compared to vehicle by Fisher’s exact test. There were a minimum of n = 22 mice per cohort [n = 159 vehicle (72 female and 87 male), n = 69 mice MPEP (32 female and 37 male), n = 40 mice SB216763 (11 female and 29 male), and n = 22 mice AFC03127 (10 female and 12 male)]. Asterisks indicate statistical significance of p ≤ 0.0001 (^∗∗∗), p ≤ 0.01 (^∗∗), and p ≤ 0.05 (^∗).