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. 2021 Oct 7;12:738490. doi: 10.3389/fimmu.2021.738490

Figure 2.

Figure 2

Excessive IFN cytokine signature is observed in influenza-infected Tpl2-/- mice at 7 dpi. WT (n = 10) and Tpl2-/- (n = 9) mice were infected intranasally with 104 pfu of influenza x31 and euthanized at 7 dpi. (A–P) The lungs were homogenized for analysis of cytokine expression. Squares represent male mice, and circles represent female mice. Data are representative of 2 experiments. Unpaired student’s t-test *p<0.05, **p<0.01, ****p<0.0001. (Q) Correlation of Interferon levels in the perfused and lavaged lungs with weight loss at 7 dpi. (R) Correlation of viral titers in the perfused and lavaged lungs with weight loss at 7 dpi. Data are representative of 2 experiments. Two tailed Pearson’s Correlation test was performed *p<0.05.