Figure 5.

Ineffective suppression of CCL2 protein levels despite transcriptional repression in influenza-infected Tpl2^-/- mice at 9 dpi. WT (n = 5) and Tpl2^-/- (n = 5) mice were infected intranasally with 10⁴ pfu of influenza x31 and euthanized at 9 dpi. (A–O) WT (14) & Tpl2^-/- (11) lungs were homogenized and analyzed for gene expression for transcriptional regulators (A–E), pro-inflammatory cytokines (F–I), anti-inflammatory cytokines (J), chemokines (K, L) and inflammatory mediators (M–O). (P–W) The lungs were homogenized and assessed for cytokine protein levels. Squares represent male mice, and circles represent female mice. Data are representative of 2 experiments. Unpaired student’s t-test *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.