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. 2021 Oct 7;12:738490. doi: 10.3389/fimmu.2021.738490

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Copyright © 2021 Latha, Jamison and Watford

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tpl2 ablation in the radioresistant cells allows for an initial cytokine burst at 8 dpi, but chimeras recover by 10 dpi. (A) Experimental outline for infection of chimeras. WT or Tpl2^-/- mice were irradiated and given WT bone marrow to reconstitute for 2 months. They were then infected and studied for 8-10 days for clinical outcome and cytokine examination on day 8 or day 10 post infection. (B) Weight loss curve shows that the Tpl2^-/- chimeras show greater weight loss by day 8, but are able to recover their weights by day 10 post infection. Diamonds represent that the data points are averaged for males and females. (C–I) Cytokine expression at day 8 or day 10 post infection. Unpaired student’s t-test *p<0.05, **p<0.01.