TABLE 2.
Summary estimates of diagnostic performance of miR‐21 for cancer detection
| Analysis | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC (95% CI) |
|---|---|---|---|---|---|---|
| Ethnicity | ||||||
| Caucasian‐based | 0.84 (0.65, 0.94) | 0.91 (0.73, 0.98) | 9.7 (2.6, 36.6) | 0.17 (0.06, 0.46) | 56 (6, 498) | 0.95 (0.92, 0.96) |
| Asian‐based | 0.73 (0.68, 0.79) | 0.80 (0.74, 0.85) | 3.7 (2.7, 4.9) | 0.33 (0.26, 0.42) | 11 (7, 18) | 0.83 (0.8, 0.86) |
| Cancer types | ||||||
| Digestive system | 0.77 (0.68, 0.84) | 0.78 (0.71, 0.84) | 3.5 (2.4, 5.1) | 0.3 (0.2, 0.45) | 12 (6, 25) | 0.84 (0.81, 0.87) |
| Pancreatic cancer | 0.85 (0.71, 0.93) | 0.84 (0.69, 0.92) | 5.2 (2.5, 11) | 0.17 (0.08, 0.39) | 30 (7, 124) | 0.91 (0.88, 0.93) |
| PDAC | 0.76 (0.68, 0.84) | 0.74 (0.61, 0.85) | 2.7 (1.23, 5.91) | 0.32 (0.14, 0.74) | 11.75 (2.14, 64.65) | 0.85 (0.74, 0.98) |
| Gastric cancer | 0.65 (0.53, 0.75) | 0.77 (0.65, 0.87) | 2.82 (1.76, 4.51) | 0.37 (0.13, 1.1) | 7.52 (2, 28.26) | N.A. |
| Breast cancer | 0.76 (0.58, 0.89) | 0.85 (0.69, 0.95) | 4.24 (1.92, 9.35) | 0.30 (0.16, 0.54) | 14.71 (4.20, 51.58) | N.A. |
| NSCLC | 0.70 (0.64, 0.77) | 0.78 (0.64, 0.88) | 3.00 (1.82, 4.94) | 0.34 (0.14, 0.79) | 9.73 (3.11, 30.46) | 0.85 (0.71, 0.98) |
| Other types | 0.71 (0.65, 0.78) | 0.87 (0.79, 0.92) | 5.4 (3.1, 9.1) | 0.33 (0.25, 0.43) | 16 (7, 35) | 0.85 (0.81, 0.87) |
| Sample types | ||||||
| Plasma‐based | 0.79 (0.69, 0.86) | 0.79 (0.73, 0.84) | 3.8 (2.9, 5) | 0.27 (0.18, 0.4) | 14 (8, 20) | 0.85 (0.81, 0.88) |
| Serum‐based | 0.74 (0.54, 0.87) | 0.84 (0.62, 0.95) | 4.8 (1.4, 16.1) | 0.31 (0.14, 0.7) | 15 (2, 115) | 0.86 (0.83, 0.89) |
| Other types | 0.75 (0.66, 0.82) | 0.86 (0.76, 0.92) | 5.4 (2.9, 10.2) | 0.29 (0.20, 0.43) | 18 (7, 50) | 0.87 (0.84, 0.89) |
| Overall | 0.76 (0.70–0.81) | 0.82 (0.77–0.87) | 4.34 (3.14 – 5.99) | 0.29 (0.22 – 0.38) | 15 (8–26) | 0.86 (0.83–0.89) |
| Two outliers excluded | 0.73 (0.67–0.78) | 0.81 (0.76–0.85) | 3.8 (2.9–5.0) | 0.34 (0.27–0.42) | 11 (7–18) | 0.84 (0.80–0.87) |
Abbreviations: AUC, area under the curve; DOR, diagnostic odds ratios; N.A., not applicable; NLR, negative likelihood ratio; NSCLC, non‐small‐cell lung cancer; PDAC, pancreatic ductal adenocarcinoma; PLR, positive likelihood ratio.