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. 2021 Oct 7;11:750794. doi: 10.3389/fonc.2021.750794

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Copyright © 2021 Zuo, Chen, Chen, Kang, Shi, Liu, Zhang, Jia, Huang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Receiver operating characteristic (ROC) curves of plasma metabolites with area under the curve (AUC) values exceeding 0.9. ROC curves of (A) thromboxane B2, (B) succinic acid, (C) glutamine, and (D) hypoxanthine. The AUCs of thromboxane B2, succinic acid, glutamine, and hypoxanthine were 0.944 (95% CI = 0.887–0.98), 0.926 (95% CI = 0.875–0.965), 0.922 (95% CI = 0.87–0.961), and 0.905 (95% CI = 0.855–0.947), respectively. The box plots show the median, the quartiles, and the whole range of peak area of these metabolites.