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. 2021 Oct 7;11:750794. doi: 10.3389/fonc.2021.750794

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Copyright © 2021 Zuo, Chen, Chen, Kang, Shi, Liu, Zhang, Jia, Huang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Succinic acid change-low and hypoxanthine change-high had high predictive accuracy for 3-year recurrence-free survival (RFS). receiver operating characteristic (ROC) curves indicating the predictive accuracy, sensitivity, and specificity of each potential parameter. The area under the curve (AUC) values of succinic acid change-low, hypoxanthine change-high, tumor stage, and tumor grade (differentiation) were 0.743 (95% CI = 0.627–0.859), 0.794 (95% CI = 0.686–0.903), 0.775 (95% CI = 0.664–0.885), and 0.747 (95% CI = 0.629–0.864), respectively; but succinic acid change-low combined with hypoxanthine change-high and tumor grade provided the highest predictive accuracy (AUC = 0.900; 95% CI = 0.822–0.967).